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Bioclinic Naturals

Digest-ProGD HP 60 capsules

Regular price $23.99 USD
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Digest-ProGD is a broad spectrum proprietary enzyme blend, providing unique support for the digestion of gluten and dairy proteins, as well as lactose, other carbohydrates, proteins and fats. It contains Dipeptidyl peptidase IV (DPP-IV), a multifunctional serine protease that targets proline containing peptides, such as those found in gliadin and casein, which are both proteolytically resistant proteins.1, 2, 3 DPP-IV is thought to be one of the rate limiting enzymes responsible for the digestion of these proteins. It is known to be found in lower amounts in the intestinal mucosa of individuals with celiac disease and to have an inverse correlation with the level of mucosal damage among those with and without celiac disease.4, 5 The antigenic and immunomodulatory proline-rich proteins found in gluten are thought to trigger an inflammatory response in patients with either celiac disease or gluten sensitivity, often due to inadvertent gluten exposure, even for those on a gluten free diet.6 Digest-ProGD provides comprehensive digestive support, containing multiple proteases as well as enzymes necessary for lipid and carbohydrate metabolism.
Contains essential proteases I, II, III, IV and IV, stable throughout the pH range of the digestive tract
Each capsule delivers a standardized level of DPP-IV activity and is shown to survive the harsh environment of the stomach
Hydrolyzes difficult-to-digest proline-containing peptides such as gluten and casein
Contains amylase and glucoamylase that assist in the hydrolysis of carbohydrates as well as the enzyme lactase
Provides alpha-galactosidase for the digestion of oligosaccharides found in beans, other legumes and cruciferous vegetables
Suitable for vegetarians/vegans, and gluten and casein free diets
1. Mulvihill EE, Drucker DJ. Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr Rev. 2014 Dec;35(6):992-1019. doi:10.1210/er.2014-1035.
2. Nongonierma AB, FitzGerald RJ. Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis. Food Chem. 2014 Feb 15;145:845-52. doi:10.1016/j. foodchem.2013.08.097.
3. Lambeir AM, Durinx C, Scharpé S, De Meester I. Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci. 2003 Jun;40(3):209-94.
4. Hausch F, Shan L, Santiago NA, et al. Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G996-G1003.
5. Detel D, Persic M, Varljen J. Serum and intestinal dipeptidyl peptidase IV (DPP IV/CD26) activity in children with celiac disease. J Pediatr Gastroenterol Nutr. 2007 Jul;45(1):65-70.
6. Cerf-Bensussan N, Matysiak-Budnik T, Cellier C, Heyman M. Oral proteases: a new approach to managing coeliac disease. Gut. 2007 Feb;56(2):157-60. Epub 2006 Sep 1.
Take 1–2 capsules per day with meals or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks.
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
Proprietary Enzyme Blend ... 375mg
Fungal Protease ... 247.5mg (33, 750 FCC HUT)
(Aspergillus flavus var. oryzae)(whole)
Bacterial Protease ... 9.375mg (937.5 FCC PC)
(Bacillus subtilis)(whole cell)
Serratiopeptidase ... 37.5mg (3, 750 SU)
(Serratia marcescens)(whole cell)
Bromelain ... 2.344mg (37, 500 FCC PU)
(Ananas comosus var. comosus)(stem)
Papain ... 1.2375mg (37, 500 FCC PU)
(Carica papaya)(fruit)
Cellulase ... 0.75mg (75 FCC CU)
(Trichoderma reesei)(whole)
Lactase ... 4.275mg (153.75 FCC ALU)
(Aspergillus flavus var. oryzae)(whole)
Alpha-Amylase ... 18.75mg (1875 FCC DU)
(Aspergillus flavus var. oryzae)(whole)
Alpha-Amylase ... 37.5mg (375 FCC BAU)
(Bacillus subtilis)(whole cell)
Glucoamylase ... 11.25mg (11.25 FCC AGU)
(Aspergillus niger)(whole)
Lipase ... 0.9375mg (112.5 FCC LU)
(Candida rugosa)(whole)
Alpha-Galactosidase ... 3.75mg (37.5 FCC GalU)
(Aspergillus niger)(whole)
Other Ingredients: Rice starch, vegetarian capsule (carbohydrate gum [cellulose], purified water, silica), vegetable grade magnesium stearate (lubricant).
This product does not contain
artificial colors
artificial preservatives
artificial sweeteners
animal products
tree nuts
Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Consult a health care practitioner if symptoms persist or worsen. Consult a health care practitioner prior to use if you have diabetes, a gastrointestinal lesion, ulcer, are taking an anticoagulant, blood thinner, anti-inflammatory, antibiotic, or are having surgery, are pregnant or breastfeeding, or have allergy to latex or fruits (avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, tomato). Headaches, heartburn, bloating, hypersensitivity/allergy, nausea, vomiting, diarrhea, and abdominal pain/epigastric pain have been known to occur, in which case discontinue use. Keep out of reach of children.


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